Death , and Senescence lin-Dependent Kinase 4 – Mediated Phosphorylation bits Smad 3 Activity in Cyclin D – Overexpressing R ast Cancer Cells

@inproceedings{Zelivianski2010DeathA,
  title={Death , and Senescence lin-Dependent Kinase 4 – Mediated Phosphorylation bits Smad 3 Activity in Cyclin D – Overexpressing R ast Cancer Cells},
  author={lav Zelivianski and Anne Cooley and Ron Kall and Jacqueline Sara Jeruss},
  year={2010}
}
ownload d3, a component of the transforming growth factor β signaling cascade, contributes to G1 arrest in cancer cells. Cyclin D1/cyclin-dependent kinase 4 (CDK4) promotes G1-S–phase transition, and CDK horylation of Smad3 has been associated with inhibition of Smad3 activity. We hypothesized that oversion of cyclin D1 exerts tumorigenic effects in breast cancer cells through CDK4-mediated phosphorand inhibition of Smad3 and release of G1 arrest. Real-time quantitative reverse transcription… CONTINUE READING
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