Deamination of methylamine and angiopathy; toxicity of formaldehyde, oxidative stress and relevance to protein glycoxidation in diabetes.

@article{Yu1998DeaminationOM,
  title={Deamination of methylamine and angiopathy; toxicity of formaldehyde, oxidative stress and relevance to protein glycoxidation in diabetes.},
  author={Peter H.F. Yu},
  journal={Journal of neural transmission. Supplementum},
  year={1998},
  volume={52},
  pages={201-16}
}
  • Peter H.F. Yu
  • Published 1998 in Journal of neural transmission. Supplementum
Semicarbazide-sensitive amine oxidase (SSAO) is located in the vascular smooth muscles, retina, kidney and the cartilage tissues, and it circulates in the blood. The enzyme activity has been found to be significantly increased in blood and tissues in diabetic patients and animals. Methylamine and aminoacetone are endogenous substrates for SSAO. The deaminated products are formaldehyde and methylglyoxal respectively, as well as H2O2 and ammonia, which are all potentially cytotoxic. Formaldehyde… CONTINUE READING

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