Deamination of 5-hydroxytryptamine by both forms of monoamine oxidase in the rat brain.

@article{Fowler1982DeaminationO5,
  title={Deamination of 5-hydroxytryptamine by both forms of monoamine oxidase in the rat brain.},
  author={Christopher J Fowler and Keith F. Tipton},
  journal={Journal of neurochemistry},
  year={1982},
  volume={38 3},
  pages={733-6}
}
Km and Vmax values of monoamine oxidase (MAO) A and B towards 5-hydroxytryptamine were determined for rat brain homogenates after the in vitro inhibition of one of the two forms by the selective inhibitors clorgyline and l-deprenyl. Km values of 178 and 1170 microM, and Vmax values of 0.73 and 0.09 nmol . mg protein-1 . min-1 towards 5-hydroxytryptamine were found for MAO-A and -B, respectively. The Ki for 5-hydroxytryptamine as a competitive inhibitor of beta-phenethylamine oxidation by MAO-B… CONTINUE READING

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