Deamidated Lipocalin‐2 Induces Endothelial Dysfunction and Hypertension in Dietary Obese Mice

@inproceedings{Song2014DeamidatedLI,
  title={Deamidated Lipocalin‐2 Induces Endothelial Dysfunction and Hypertension in Dietary Obese Mice},
  author={Erfei Song and Pengcheng Fan and Bosheng Huang and Han‐Bing Deng and Bernard Man Yung Cheung and Michel F{\'e}l{\'e}tou and Jean‐Paul Vilaine and Nicole Villeneuve and Aimin Xu and Paul Michel Vanhoutte and Yu Wang},
  booktitle={Journal of the American Heart Association},
  year={2014}
}
BACKGROUND Lipocalin-2 is a proinflammatory adipokine upregulated in obese humans and animals. A pathogenic role of lipocalin-2 in hypertension has been suggested. Mice lacking lipocalin-2 are protected from dietary obesity-induced cardiovascular dysfunctions. Administration of lipocalin-2 causes abnormal vasodilator responses in mice on a high-fat diet (HFD). METHODS AND RESULTS Wild-type and lipocalin-2 knockout mice were fed with standard chow or HFD. Immunoassays were performed for… CONTINUE READING
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