Deamidase inactivates a D-amino acid-containing Aplysia neuropeptide.

  title={Deamidase inactivates a D-amino acid-containing Aplysia neuropeptide.},
  author={Fumihiro Morishita and Osamu Matsushima and Yasuo Furukawa and Hiroyuki Minakata},
  volume={24 1},
Membrane-catalyzed degradation of the cardioexcitatory peptide, Asn-D-Trp-Phe-NH(2) (N(d)WF-NH(2)), which was previously isolated from Aplysia, was investigated in relation to its inactivation mechanism. The principal degradation was deamidation of the C-terminal amide, producing biologically inert Asn-D-Trp-Phe-OH (N(d)WF-OH). Among membrane fractions… CONTINUE READING