Dealkylation of phosphonate esters with chlorotrimethylsilane.


Chlorotrimethylsilane completely dealkylates phosphonate esters at elevated temperature in a sealed reaction vessel. These conditions are tolerated by a variety of functional groups and lead to high conversions of dimethyl, diethyl and diisopropyl phosphonates to their corresponding phosphonic acids. 


Cite this paper

@article{Gutierrez2001DealkylationOP, title={Dealkylation of phosphonate esters with chlorotrimethylsilane.}, author={Alfonso Jimenez Gutierrez and E J Prisbe and John C. Rohloff}, journal={Nucleosides, nucleotides & nucleic acids}, year={2001}, volume={20 4-7}, pages={1299-302} }