Deafness in mice lacking the T-box transcription factor Tbx18 in otic fibrocytes.

Abstract

In the cochlea, fibrocytes play important physiological roles, including the maintenance of the ionic composition of the endolymph. Human deafness upon fibrocyte alterations witnesses their crucial role for hearing. We demonstrate that differentiation of otic fibrocytes requires the T-box transcription factor gene Tbx18. Tbx18 expression during inner ear… (More)
DOI: 10.1242/dev.014043

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@article{Trowe2008DeafnessIM, title={Deafness in mice lacking the T-box transcription factor Tbx18 in otic fibrocytes.}, author={Mark-Oliver Trowe and Hannes Maier and Michaela Schweizer and Andreas Kispert}, journal={Development}, year={2008}, volume={135 9}, pages={1725-34} }