Deafness disrupts chloride transporter function and inhibitory synaptic transmission.

@article{Vale2003DeafnessDC,
  title={Deafness disrupts chloride transporter function and inhibitory synaptic transmission.},
  author={Carmen Vale and Jon Schoorlemmer and Dan H. Sanes},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 20},
  pages={7516-24}
}
Loss of sensory function leads to atrophy or death within the developing CNS, yet little is known about the physiology of remaining synapses. After bilateral deafening, gramicidin-perforated-patch recordings were obtained from gerbil inferior colliculus neurons in a brain slice preparation. Afferent-evoked IPSPs had a diminished ability to block current-evoked action potentials in deafened neurons. This change could be attributed, in part, to a loss of potassium-dependent chloride transport… CONTINUE READING
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Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K ]o regulation

  • JA Payne
  • Am J Physiol 273:C1516
  • 1997
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