Deafness and permanently reduced potassium channel gene expression and function in hypothyroid Pit1dw mutants.

@article{Mustapha2009DeafnessAP,
  title={Deafness and permanently reduced potassium channel gene expression and function in hypothyroid Pit1dw mutants.},
  author={Mirna Mustapha and Qing Fang and T. -W. L. Gong and David F. Dolan and Yehoash Raphael and Sally A Camper and Robert Keith Duncan},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 4},
  pages={1212-23}
}
The absence of thyroid hormone (TH) during late gestation and early infancy can cause irreparable deafness in both humans and rodents. A variety of rodent models have been used in an effort to identify the underlying molecular mechanism. Here, we characterize a mouse model of secondary hypothyroidism, pituitary transcription factor 1 (Pit1(dw)), which has profound, congenital deafness that is rescued by oral TH replacement. These mutants have tectorial membrane abnormalities, including a… CONTINUE READING
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