Deafferentation weakens excitatory synapses in the developing central auditory system.

@article{Kotak1997DeafferentationWE,
  title={Deafferentation weakens excitatory synapses in the developing central auditory system.},
  author={Vibhakar C. Kotak and Dan H. Sanes},
  journal={The European journal of neuroscience},
  year={1997},
  volume={9 11},
  pages={2340-7}
}
Decreased excitatory synaptic activity during development often leads to pre- and postsynaptic atrophy, as assessed anatomically. The present study considers the effect of decreased excitatory transmission on the maturation of synaptic strength. Towards this end, cochlear nucleus neurons, which project to the ipsilateral lateral superior olive (LSO), were denervated in gerbils at postnatal day 7, before the onset of hearing. This manipulation was intended to disrupt spontaneous glutamatergic… CONTINUE READING
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