Deafferentation causes apoptosis in cortical sensory neurons in the adult rat.

@article{Capurso1997DeafferentationCA,
  title={Deafferentation causes apoptosis in cortical sensory neurons in the adult rat.},
  author={Sabrina A Capurso and Michael E. Calhoun and R. R. Sukhov and Peter R. Mouton and Donald L. Price and Vassilis E. Koliatsos},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1997},
  volume={17 19},
  pages={7372-84}
}
The present study provides an experimental model of the apoptotic death of pyramidal neurons in rat olfactory cortex after total bulbectomy. Terminal transferase (TdT)-mediated deoxyuridine triphosphate (d-UTP)-biotin nick end labeling (TUNEL), DNA electrophoresis, and neuronal ultrastructure were used to provide evidence of apoptosis; neurons in olfactory cortex were counted by stereology. Maximal TUNEL staining occurred in the piriform cortex between 18 and 26 hr postbulbectomy. Within the… CONTINUE READING

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