Deafferentation causes apoptosis in cortical sensory neurons in the adult rat.

  title={Deafferentation causes apoptosis in cortical sensory neurons in the adult rat.},
  author={Sabrina A Capurso and Michael E. Calhoun and R. R. Sukhov and Peter R. Mouton and Donald L. Price and Vassilis E. Koliatsos},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={17 19},
The present study provides an experimental model of the apoptotic death of pyramidal neurons in rat olfactory cortex after total bulbectomy. Terminal transferase (TdT)-mediated deoxyuridine triphosphate (d-UTP)-biotin nick end labeling (TUNEL), DNA electrophoresis, and neuronal ultrastructure were used to provide evidence of apoptosis; neurons in olfactory cortex were counted by stereology. Maximal TUNEL staining occurred in the piriform cortex between 18 and 26 hr postbulbectomy. Within the… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 28 extracted citations


Publications referenced by this paper.
Showing 1-10 of 66 references

Definition and incidence of apoptosis: an historical perspective

  • JFR Kerr, BV Harmon
  • 1991
Highly Influential
4 Excerpts

Ventral root

  • VE Koliatsos, WL Price, CA Pardo, DL Price
  • 1994
Highly Influential
4 Excerpts

The fine structure of the nervous system

  • A Peters, SL Palay, HF Webster
  • 1991
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…