Deadenylation is a widespread effect of miRNA regulation.

Abstract

miRNAs silence gene expression by repressing translation and/or by promoting mRNA decay. In animal cells, degradation of partially complementary miRNA targets occurs via deadenylation by the CAF1-CCR4-NOT1 deadenylase complex, followed by decapping and subsequent exonucleolytic digestion. To determine how generally miRNAs trigger deadenylation, we compared… (More)
DOI: 10.1261/rna.1399509

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@article{Eulalio2009DeadenylationIA, title={Deadenylation is a widespread effect of miRNA regulation.}, author={Ana Eulalio and Eric Huntzinger and Tadashi Nishihara and Jan Rehwinkel and Maria Fauser and Elisa Izaurralde}, journal={RNA}, year={2009}, volume={15 1}, pages={21-32} }