Deadenylation and P-bodies.

  title={Deadenylation and P-bodies.},
  author={C A Chen and A B Shyu},
  journal={Advances in experimental medicine and biology},
Deadenylation is the major step in triggering mRNA decay and results in mRNA translation inhibition in eukaryotic cells. Therefore, it is plausible that deadenylation also induces the mRNP remodeling required for formation of GW bodies or RNA processing bodies (P-bodies), which harbor translationally silenced mRNPs. In this chapter, we discuss several examples to illustrate the roles of deadenylation in regulating gene expression. We highlight several lines of evidence indicating that even… CONTINUE READING
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