Dead-End Elimination with Backbone Flexibility


MOTIVATION Dead-End Elimination (DEE) is a powerful algorithm capable of reducing the search space for structure-based protein design by a combinatorial factor. By using a fixed backbone template, a rotamer library, and a potential energy function, DEE identifies and prunes rotamer choices that are provably not part of the Global Minimum Energy Conformation… (More)
DOI: 10.1093/bioinformatics/btm197


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