Deactivation of TSH receptor signaling in filter-cultured pig thyroid epithelial cells.

@article{Ericson2000DeactivationOT,
  title={Deactivation of TSH receptor signaling in filter-cultured pig thyroid epithelial cells.},
  author={Lars E. Ericson and Mikael Nilsson},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2000},
  volume={278 4},
  pages={
          E611-9
        }
}
  • L. Ericson, M. Nilsson
  • Published 1 April 2000
  • Biology, Medicine
  • American journal of physiology. Endocrinology and metabolism
Thyrotropin [thyroid-stimulating hormone (TSH)] receptor on-off signaling was studied in polarized monolayers of pig thyrocytes cultured on permeable support. Transepithelial resistance (R) and potential difference (PD) were used as parameters to monitor the effect of altered TSH concentrations on vectorial electrolyte transport. TSH induced rapid but long-lasting changes in R (decrease) and PD (increase) that were cAMP-dependent and related to enhanced transcellular conductance of sodium and… 
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Kinetics of thyrotropin-stimulating hormone (TSH) and thyroid-stimulating antibody binding and action on the TSH receptor in intact TSH receptor-expressing CHO cells.
TLDR
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Amiodarone inhibits thyroidal iodide transport in vitro by a cyclic adenosine 5'-monophosphate- and iodine-independent mechanism.
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AM blocks thyroidal iodide uptake by reducing the iodide permeability of the apical plasma membrane of the thyroid epithelial cells, which is iodine independent and long-lasting and does not involve impaired function of NIS or the TSH receptor/cAMP signaling pathway.
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The molecular phenotype of the adenomas thus confirms the role of long-term stimulation of the TSH-cAMP cascade in the pathology and suggests that in tumorigenesis, activation of proliferation pathways may be complemented by suppression of multiple corresponding negative feedbacks, i.e., specific tumor suppressors.
Switching from MAPK-dependent to MAPK-independent repression of the sodium-iodide symporter in 2D and 3D cultured normal thyroid cells
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TLDR
The aim of this study was to investigate the effects of (131)I irradiation on (125)I(-) transport and cell proliferation at low absorbed doses in vitro and to suggest that radiation-induced thyroid stunning and cell cycle arrest may be independent phenomena.
Thyroid disruptor 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) prevents internalization of TSH receptor
TLDR
It was shown that a 1-min exposure to TSH sufficed to displace anti-TSHr antibodies tagged with 10-nm gold particles into coated pits and vesicles but that their superficial location was retained along the plasma membrane in the presence of DDT.
Progesterone Upregulates Gene Expression in Normal Human Thyroid Follicular Cells
TLDR
Examination of progesterone effects in the sodium-iodide symporter NIS, thyroglobulin TG, thyroperoxidase TPO, and KI-67 genes expression suggests genes involved in thyroid cell function and proliferation are upregulated by progester one.
Linking loss of sodium-iodide symporter expression to DNA damage.
Swelling- and TSH-stimulated Taurine Efflux in Rat Thyroid Cells (FRTL-5) Grown on Permeable Membranes
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This document summarizes current capabilities, research and operational priorities, and plans for further studies that were established at the 2015 USGS workshop on quantitative hazard assessments of earthquake-triggered landsliding and liquefaction in the Central American region.

References

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TLDR
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