Deacetylases and NF-kappaB in redox regulation of cigarette smoke-induced lung inflammation: epigenetics in pathogenesis of COPD.

@article{Rajendrasozhan2008DeacetylasesAN,
  title={Deacetylases and NF-kappaB in redox regulation of cigarette smoke-induced lung inflammation: epigenetics in pathogenesis of COPD.},
  author={Saravanan Rajendrasozhan and S R Eric Yang and Indika Edirisinghe and Hongwei Yao and David Adenuga and Irfan Rahman},
  journal={Antioxidants & redox signaling},
  year={2008},
  volume={10 4},
  pages={799-811}
}
Oxidative stress has been implicated in the pathogenesis of several inflammatory lung disorders including chronic obstructive pulmonary disease (COPD), due to its effect on pro-inflammatory gene transcription. Cigarette smoke-mediated oxidative stress activates NF-kappaB-dependent transcription of pro-inflammatory mediators either through activation of inhibitor kappaB-alpha kinase (IKK) and/or the enhanced recruitment and activation of transcriptional co-activators. Enhanced NF-kappaB-co… CONTINUE READING
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