Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis.

@article{Saouaf2009DeacetylaseII,
  title={Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis.},
  author={Sandra J Saouaf and Bin Li and Geng Zhang and Yuan Shen and Narumi Furuuchi and Wayne W Hancock and M ichael Greene},
  journal={Experimental and molecular pathology},
  year={2009},
  volume={87 2},
  pages={99-104}
}
Collagen-induced arthritis (CIA) is an established mouse model of disease with hallmarks of clinical rheumatoid arthritis. Histone/protein deacetylase inhibitors (HDACi) are known to inhibit the pathogenesis of CIA and other models of autoimmune disease, although the mechanisms responsible are unclear. Regulatory T cell (Treg) function is defective in rheumatoid arthritis. FOXP3 proteins in Tregs are present in a dynamic protein complex containing histone acetyltransferase and HDAC enzymes, and… CONTINUE READING

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