DeSUMOylating isopeptidase: a second class of SUMO protease.

  title={DeSUMOylating isopeptidase: a second class of SUMO protease.},
  author={Eun Ju Shin and Hyun Mi Shin and Eori Nam and Won Seog Kim and Ji Hoon Kim and Byung-Ha Oh and Yungdae Yun},
  journal={EMBO reports},
  volume={13 4},
The modification of proteins by small ubiquitin-like modifier (SUMO) is crucial for the regulation of diverse cellular processes. Protein SUMOylation is reversed by isopeptidases, collectively known as deSUMOylases. Only one family of SUMO-specific proteases has been described so far: the sentrin-specific proteases (SENP). Here, we identify and characterize a new deSUMOylase, which we have named DeSI-1 (DeSumoylating Isopeptidase 1). We describe BZEL—a new transcriptional repressor—as substrate… CONTINUE READING
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