De-repression of CSP-1 activates adaptive responses to antifungal azoles


Antifungal azoles are the major drugs that are used to treat fungal infections. This study found that in response to antifungal azole stress, Neurospora crassa could activate the transcriptional responses of many genes and increase azole resistance by reducing the level of conidial separation 1 (CSP-1), a global transcription repressor, at azole-responsive… (More)
DOI: 10.1038/srep19447