De novo transcriptome sequencing and digital gene expression analysis predict biosynthetic pathway of rhynchophylline and isorhynchophylline from Uncaria rhynchophylla, a non-model plant with potent anti-alzheimer’s properties

Abstract

The major medicinal alkaloids isolated from Uncaria rhynchophylla (gouteng in chinese) capsules are rhynchophylline (RIN) and isorhynchophylline (IRN). Extracts containing these terpene indole alkaloids (TIAs) can inhibit the formation and destabilize preformed fibrils of amyloid β protein (a pathological marker of Alzheimer’s disease), and have been shown… (More)
DOI: 10.1186/1471-2164-15-676

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@inproceedings{Guo2013DeNT, title={De novo transcriptome sequencing and digital gene expression analysis predict biosynthetic pathway of rhynchophylline and isorhynchophylline from Uncaria rhynchophylla, a non-model plant with potent anti-alzheimer’s properties}, author={Qianqian Guo and Xiaojun Ma and Shugen Wei and Deyou Qiu and I Wilson and Peng Wu and Qi Tang and Lijun Leo Liu and Shoukun Dong and Wei Zu}, booktitle={BMC Genomics}, year={2013} }