De novo transcriptome assembly facilitates characterisation of fast-evolving gene families, MHC class I in the bank vole (Myodes glareolus)

@article{Migalska2017DeNT,
  title={De novo transcriptome assembly facilitates characterisation of fast-evolving gene families, MHC class I in the bank vole (Myodes glareolus)},
  author={M Migalska and Aguirre Sebastian and M Konczal and P Kotl{\'i}k and J Radwan},
  journal={Heredity},
  year={2017},
  volume={118},
  pages={348-357}
}
The major histocompatibility complex (MHC) plays a central role in the adaptive immune response and is the most polymorphic gene family in vertebrates. Although high-throughput sequencing has increasingly been used for genotyping families of co-amplifying MHC genes, its potential to facilitate early steps in the characterisation of MHC variation in nonmodel organism has not been fully explored. In this study we evaluated the usefulness of de novo transcriptome assembly in characterisation of… CONTINUE READING
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