De novo subtype and strain identification of botulinum neurotoxin type B through toxin proteomics

@inproceedings{Kalb2012DeNS,
  title={De novo subtype and strain identification of botulinum neurotoxin type B through toxin proteomics},
  author={Suzanne R. Kalb and Jakub Baudys and Jon C. Rees and Theresa J. Smith and L. A. Smith and Charles H. Helma and Karen K. Hill and Skadi Kull and Sebastian Kirchner and Martin Bernhard Dorner and Brigitte G Dorner and James L. Pirkle and John R. Barr},
  booktitle={Analytical and bioanalytical chemistry},
  year={2012}
}
Botulinum neurotoxins (BoNTs) cause the disease botulism, which can be lethal if untreated. There are seven known serotypes of BoNT, A-G, defined by their response to antisera. Many serotypes are distinguished into differing subtypes based on amino acid sequence, and many subtypes are further differentiated into toxin variants. Previous work in our laboratory described the use of a proteomics approach to distinguish subtype BoNT/A1 from BoNT/A2 where BoNT identities were confirmed after… CONTINUE READING