De novo protein design. II. Plasticity in sequence space.

@article{Koehl1999DeNP,
  title={De novo protein design. II. Plasticity in sequence space.},
  author={Patrice Koehl and Michael Levitt},
  journal={Journal of molecular biology},
  year={1999},
  volume={293 5},
  pages={1183-93}
}
It is generally accepted that many different protein sequences have similar folded structures, and that there is a relatively high probability that a new sequence possesses a previously observed fold. An indirect consequence of this is that protein design should define the sequence space accessible to a given structure, rather than providing a single optimized sequence. We have recently developed a new approach for protein sequence design, which optimizes the complete sequence of a protein… CONTINUE READING
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