De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity.

@article{Yang2013DeNL,
  title={De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity.},
  author={Zhufeng Yang and Susan Zimmerman and Paul R. Brakeman and Gerard M J Beaudoin and Louis French Reichardt and Denise K Marciano},
  journal={Development},
  year={2013},
  volume={140 8},
  pages={
          1774-84
        }
}
A fundamental process in biology is the de novo formation and morphogenesis of polarized tubules. Although these processes are essential for the formation of multiple metazoan organ systems, little is known about the molecular mechanisms that regulate them. In this study, we have characterized several steps in tubule formation and morphogenesis using the mouse kidney as a model system. We report that kidney mesenchymal cells contain discrete Par3-expressing membrane microdomains that become… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 57 references

Signaling pathways in cell polarity.

Cold Spring Harbor perspectives in biology • 2012

Spatial organization of the extracellular matrix regulates cell-cell junction positioning.

Proceedings of the National Academy of Sciences of the United States of America • 2012