De novo lipogenesis in the differentiating human adipocyte can provide all fatty acids necessary for maturation.

@article{Collins2011DeNL,
  title={De novo lipogenesis in the differentiating human adipocyte can provide all fatty acids necessary for maturation.},
  author={Jennifer M. Collins and Matt J. Neville and Katherine E. Pinnick and Leanne Hodson and Bente Ruyter and Theo H. van Dijk and Dirk-Jan Reijngoud and Mark D. Fielding and Keith N. Frayn},
  journal={Journal of lipid research},
  year={2011},
  volume={52 9},
  pages={
          1683-92
        }
}
The primary products of de novo lipogenesis (DNL) are saturated fatty acids, which confer adverse cellular effects. Human adipocytes differentiated with no exogenous fat accumulated triacylglycerol (TG) in lipid droplets and differentiated normally. TG composition showed the products of DNL (saturated fatty acids from 12:0 to 18:0) together with unsaturated fatty acids (particularly 16:1n-7 and 18:1n-9) produced by elongation/desaturation. There was parallel upregulation of expression of genes… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 31 CITATIONS

Isolation, culture and differentiation of duck (Anas platyrhynchos) preadipocytes

  • Cytotechnology
  • 2014
VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Decreased adipocyte glucose transporter 4 (GLUT4) and aquaglyceroporin-7 (AQP7) in adults with morbid obesity: possible early markers of metabolic dysfunction

Roza Mourelatou, Eirini Kostopoulou, +4 authors Bessie E. Spiliotis
  • Hormones
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 27 REFERENCES

Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake

A. Vidal-Puig
  • Prog . Lipid Res .
  • 2008

Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element - binding protein - 1 c

S. O’Rahilly
  • Proc . Natl . Acad . Sci . USA .
  • 2005