De novo genome assembly: what every biologist should know

  title={De novo genome assembly: what every biologist should know},
  author={Monya Baker},
  journal={Nature Methods},
into a blank 30-million-piece jigsaw puzzle, complicated by the facts that some pieces are missing altogether and some pieces contain errors. To compensate, assemblers need about eight copies of each piece of the genome. Short-read sequencing technologies have made the computational challenge harder. Next-generation sequencers can read base pairs at a hundredth to a thousandth of the cost of Sanger sequencing, but the reads are much shorter. With short-read sequencing technologies, the human… CONTINUE READING
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