De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection.

@article{Allen2005DeNG,
  title={De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection.},
  author={Todd M. Allen and Xu G. Yu and Elizabeth T{\'a}gide Kalife and Laura L. Reyor and Mathias Lichterfeld and M. O. John and Michael M Cheng and Rachel L. Allgaier and Stanley K. Mui and Nicole Frahm and Galit Alter and Nancy V Brown and Mary N. Johnston and E. S. Rosenberg and Simon A Mallal and Christian Brander and Bruce D. Walker and Marcus Altfeld},
  journal={Journal of virology},
  year={2005},
  volume={79 20},
  pages={12952-60}
}
Human immunodeficiency virus type 1 (HIV-1) evades CD8(+) T-cell responses through mutations within targeted epitopes, but little is known regarding its ability to generate de novo CD8(+) T-cell responses to such mutants. Here we examined gamma interferon-positive, HIV-1-specific CD8(+) T-cell responses and autologous viral sequences in an HIV-1-infected individual for more than 6 years following acute infection. Fourteen optimal HIV-1 T-cell epitopes were targeted by CD8(+) T cells, four of… CONTINUE READING

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