De novo generation of an axially vascularized processed bovine cancellous-bone substitute in the sheep arteriovenous-loop model.

@article{Beier2011DeNG,
  title={De novo generation of an axially vascularized processed bovine cancellous-bone substitute in the sheep arteriovenous-loop model.},
  author={Justus Patrick Beier and A. Hess and Jiř{\'i} L{\"o}w and Johanna Heinrich and Anja M Boos and Andreas Arkudas and Elias P. Polykandriotis and Oliver A Bleiziffer and Raymund E Horch and Ulrich Kneser},
  journal={European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes},
  year={2011},
  volume={46 3},
  pages={148-55}
}
BACKGROUND/AIMS The aim of this study was to generate an axially vascularized bone substitute. The arteriovenous (AV)-loop approach in a large-animal model was applied in order to induce axial vascularization in a clinically approved processed bovine cancellous bone (PBCB) matrix of significant volume with primary mechanical stability and to assess the course of increasing axial vascularization. METHODS PBCB constructs were implanted into 13 merino sheep together with a microsurgically… CONTINUE READING
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