De novo formation of nucleoli in developing mouse embryos originating from enucleolated zygotes.


The large, compact oocyte nucleoli, sometimes referred to as nucleolus precursor bodies (NPBs), are essential for embryonic development in mammals; in their absence, the oocytes complete maturation and can be fertilized, but no nucleoli are formed in the zygote or embryo, leading to developmental failure. It has been convincingly documented that zygotes… (More)
DOI: 10.1242/dev.106948

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