De novo expression of podocyte proteins in parietal epithelial cells in experimental aging nephropathy.

@article{Zhang2012DeNE,
  title={De novo expression of podocyte proteins in parietal epithelial cells in experimental aging nephropathy.},
  author={Jiong Yi Zhang and Kim M. Hansen and Jeffrey W. Pippin and Alice M Chang and Yoshinori Taniguchi and Ronald D. Krofft and Scott G. Pickering and Zhihong Liu and Christine K. Abrass and Stuart J. Shankland},
  journal={American journal of physiology. Renal physiology},
  year={2012},
  volume={302 5},
  pages={F571-80}
}
A progressive decrease in podocyte number underlies the development of glomerulosclerosis and reduced kidney function in aging nephropathy. Recent data suggest that under certain disease states, parietal epithelial cells (PECs) begin to express proteins considered specific to podocytes. To determine whether this phenomenon increases in aging kidneys, 4-, 12-, and 20-mo ad libitum-fed and 20-mo calorie-restricted (CR) rats were studied. Single and double immunostaining were performed with… CONTINUE READING

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Glomerular parietal cells of adult murine kidney undergo EMT to generate cells with traits of renal progenitors

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