De novo expression of CD44 variants in sporadic and hereditary gastric cancer

  title={De novo expression of CD44 variants in sporadic and hereditary gastric cancer},
  author={Cristiana Branco da Cunha and Carla M Oliveira and Xiaogang Wen and B{\'a}rbara Pereira Gomes and Sonia M. Sousa and Gianpaolo Suriano and Maritie Grellier and David G. Huntsman and F{\'a}tima Carneiro and Pedro L Granja and Raquel Seruca},
  journal={Laboratory Investigation},
CD44 is the major ubiquitously expressed cell surface receptor for hyaluronate. The CD44 gene encodes several protein isoforms due to extensive alternative splicing and post-translational modifications. Some of these CD44 variable isoforms have been foreseen as key players in malignant transformation and their expression is highly restricted and highly specific, unlike the canonical CD44 standard isoform. In this study, we aimed at dissecting the mRNA splicing pattern of CD44 in normal stomach… CONTINUE READING
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