De novo discovery of a tissue-specific gene regulatory module in a chordate.

@article{Johnson2005DeND,
  title={De novo discovery of a tissue-specific gene regulatory module in a chordate.},
  author={David Scott Johnson and Qing Jin Zhou and Kasumi Yagi and Nori Satoh and Wing Wong and Arend Sidow},
  journal={Genome research},
  year={2005},
  volume={15 10},
  pages={
          1315-24
        }
}
We engage the experimental and computational challenges of de novo regulatory module discovery in a complex and largely unstudied metazoan genome. Our analysis is based on the comprehensive characterization of regulatory elements of 20 muscle genes in the chordate, Ciona savignyi. Three independent types of data we generate contribute to the characterization of a muscle-specific regulatory module: (1) Positive elements (PEs), short sequences sufficient for strong muscle expression that are… CONTINUE READING

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