De novo design and molecular assembly of a transmembrane diporphyrin-binding protein complex.

Abstract

The de novo design of membrane proteins remains difficult despite recent advances in understanding the factors that drive membrane protein folding and association. We have designed a membrane protein PRIME (PoRphyrins In MEmbrane) that positions two non-natural iron diphenylporphyrins (Fe(III)DPP's) sufficiently close to provide a multicentered pathway for… (More)
DOI: 10.1021/ja107487b

Topics

4 Figures and Tables

Cite this paper

@article{Korendovych2010DeND, title={De novo design and molecular assembly of a transmembrane diporphyrin-binding protein complex.}, author={Ivan V Korendovych and Alessandro Senes and Yong Ho Kim and James Lear and H Christopher Fry and Michael J Therien and J. Kent Blasie and Francis A. Walker and William F. DeGrado}, journal={Journal of the American Chemical Society}, year={2010}, volume={132 44}, pages={15516-8} }