De novo design and characterization of a helical hairpin eicosapeptide; emergence of an anion receptor in the linker region.

Abstract

De novo design of supersecondary structures is expected to provide useful molecular frameworks for the incorporation of functional sites as in proteins. A 21 residue long, dehydrophenylalanine-containing peptide has been de novo designed and its crystal structure determined. The apolar peptide folds into a helical hairpin supersecondary structure with two… (More)

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