De novo deciphering three-dimensional chromatin interaction and topological domains by wavelet transformation of epigenetic profiles

@inproceedings{Chen2016DeND,
  title={De novo deciphering three-dimensional chromatin interaction and topological domains by wavelet transformation of epigenetic profiles},
  author={Yong Chen and Yunfei Wang and Zhenyu Xuan and Min Chen and Michael Q. Zhang},
  booktitle={Nucleic acids research},
  year={2016}
}
Defining chromatin interaction frequencies and topological domains is a great challenge for the annotations of genome structures. Although the chromosome conformation capture (3C) and its derivative methods have been developed for exploring the global interactome, they are limited by high experimental complexity and costs. Here we describe a novel computational method, called CITD, for de novo prediction of the chromatin interaction map by integrating histone modification data. We used the… CONTINUE READING
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