De novo childhood myelodysplastic/myeloproliferative disease with unique molecular characteristics.

@article{Ismael2012DeNC,
  title={De novo childhood myelodysplastic/myeloproliferative disease with unique molecular characteristics.},
  author={Olfat Ismael and Akira Shimada and Asahito Hama and Momen Elshazley and Hideki Muramatsu and Aya Goto and Hirotoshi Sakaguchi and Makito Tanaka and Yoshiyuki Takahashi and Xu Yinyan and Minoru Fukuda and Yuji Miyajima and Yuka Yamashita and Keizo Horibe and Ryoji Hanada and Masafumi Ito and Seiji Kojima},
  journal={British journal of haematology},
  year={2012},
  volume={158 1},
  pages={129-37}
}
Myelodysplastic/myeloproliferative uclassifiable (MDS/MPN-U) is a rare myeloid neoplasm characterized by myelodysplasia and myeloproliferation at the time of initial presentation, which is usually a diagnosis of exclusion. The molecular pathogenesis of MDS/MPN-U patients remains to be elucidated. Among five patients diagnosed with MDS/MPN-U, three patients harboured RUNX1 (AML1) mutations; one carried somatic mosaicism of RUNX1 mutation with JAK2(V617F) mutation and one had dual RUNX1 and FLT3… CONTINUE READING
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