De novo ceramide synthesis is required for N-linked glycosylation in plasma cells.

Abstract

Plasma cells (PCs) are terminally differentiated B lymphocytes responsible for the synthesis and secretion of Igs. The differentiation of B cells into PCs involves a remarkable expansion of both lipid and protein components of the endoplasmic reticulum. Despite their importance in many signal transduction pathways, the role of ceramides, and of complex… (More)
DOI: 10.4049/jimmunol.0802990

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