De novo biosynthesis and radiolabeling of mammalian digitalis-like factors.

@article{Qazzaz2004DeNB,
  title={De novo biosynthesis and radiolabeling of mammalian digitalis-like factors.},
  author={Hassan M. Hussien Qazzaz and Zhimin Cao and Duane Bolanowski and Barbara J. Clark and Roland Jr. Valdes},
  journal={Clinical chemistry},
  year={2004},
  volume={50 3},
  pages={
          612-20
        }
}
BACKGROUND Digoxin-like immunoreactive factors (DLIFs) are endogenous mammalian cardenolides with structural features similar to those of the plant-derived digitalis compounds. DLIFs and their structurally related forms (Dh-DLIFs) may serve as effectors of ion-transport activity mediated by their interaction with Na,K-ATPase and thus play a role as a new hormonal axis. Although some evidence implicates the adrenal gland as a tissue source for the DLIFs, little is known about the biosynthetic… 

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