De novo autoimmunity to cardiac myosin after heart transplantation and its contribution to the rejection process.

@article{Fedoseyeva1999DeNA,
  title={De novo autoimmunity to cardiac myosin after heart transplantation and its contribution to the rejection process.},
  author={Eugenia V. Fedoseyeva and Feng Zhang and Patricia L. Orr and David E. Levin and Harry J. Buncke and Gilles Benichou},
  journal={Journal of immunology},
  year={1999},
  volume={162 11},
  pages={6836-42}
}
Allograft rejection is initiated by an immune response to donor MHC proteins. We recently reported that this response can result in breakdown of immune tolerance to a recipient self Ag. However, the contribution of this autoimmune response to graft rejection has yet to be determined. Here, we found that after mouse allogeneic heart transplantation, de novo CD4+ T cell and B cell autoimmune response to cardiac myosin (CM), a major contractile protein of cardiac muscle, is elicited in recipients… CONTINUE READING