De novo apparently balanced translocations in man are predominantly paternal in origin and associated with a significant increase in paternal age.

@article{Thomas2010DeNA,
  title={De novo apparently balanced translocations in man are predominantly paternal in origin and associated with a significant increase in paternal age.},
  author={Nick S. T. Thomas and Joan K Morris and Julia Baptista and Bee Ling Ng and John Anthony Crolla and Patricia A. Jacobs},
  journal={Journal of medical genetics},
  year={2010},
  volume={47 2},
  pages={112-5}
}
BACKGROUND Congenital chromosome abnormalities are relatively common in our species and among structural abnormalities the most common class is balanced reciprocal translocations. Determining the parental origin of de novo balanced translocations may provide insights into how and when they arise. While there is a general paternal bias in the origin of non-recurrent unbalanced rearrangements, there are few data on parental origin of non-recurrent balanced rearrangements. METHODS The parental… CONTINUE READING

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