De novo alveolar bone formation adjacent to endosseous implants.

  title={De novo alveolar bone formation adjacent to endosseous implants.},
  author={Tord Berglundh and Ingemar Abrahamsson and Niklaus P. Lang and Jan Lindhe},
  journal={Clinical oral implants research},
  volume={14 3},
OBJECTIVE To describe a model for the investigation of different phases of wound healing that are involved in the process resulting in osseointegration. MATERIAL AND METHODS The implants used for the study of early healing had a geometry that corresponded to that of a solid screw implant with an SLA surface configuration. A circumferential trough had been prepared within the thread region (intra-osseous portion) that established a geometrically well-defined wound compartment. Twenty Labrador… 

Early bone formation adjacent to rough and turned endosseous implant surfaces. An experimental study in the dog.

While healing showed similar characteristics with resorptive and appositional events for both SLA and T surfaces, the rate and degree of osseointegration were superior for the SLA compared with the T chambers.

Bone-healing pattern at the surface of titanium implants: an experimental study in the dog.

Osseointegration (new bone-to-implant contact) developed at various rates for cortical and trabecular compartments, respectively, with mesenchymal cells identified, subsequently developing into new bone in contact with the implant surface.

Osteogenesis at implants without primary bone contact - an experimental study in dogs.

Osseointegration was observed at the test sites, and the dimensions of the defects influenced the outcomes, however, the degree of osseointedegration at both small and large defects was very low compared with the control sites.

Morphometric evaluation of the early stages of healing at cortical and marrow compartments at titanium implants: an experimental study in the dog

While in the compact compartments, bone apposition had to develop through the BMUs following resorption, it developed in very dense layers through an early apposition in the marrow compartments.

Early cellular responses in cortical bone healing around unloaded titanium implants: an animal study.

The insertion of an implant into bone initiates a series of biologic processes, including the formation of a hematoma, altered nuclear morphology of the osteocytes surrounding the implantation site, intensive bone remodeling, and theformation of new bone, eventually leading to the osseointegration of the implant.

The role of bone debris in early healing adjacent to hydrophilic and hydrophobic implant surfaces in man.

The decrease in BD : ST ratio suggests that bone debris, created during implant installation and adhering to moderately rough surfaces, significantly contributed to the initiation of bone deposition and mediated the connection between the old bone and the new bone on the implant surface.

Histomorphologic and histomorphometric evaluation of various endosseous implant healing chamber configurations at early implantation times: a study in dogs.

Regardless of healing chamber design and dimensions considered, healing allowed the devices osseointegration, however, healing chamber configuration significantly affected osseointedegration measurable parameters such as BIC.

Early healing of implants placed into fresh extraction sockets: an experimental study in the beagle dog. De novo bone formation.

Osseointegration occurred similarly at both implant groups, although the socket dimension appeared to influence bone healing and it is suggested that the enhanced nano-topography has a limited effect in the immediate implant surgical protocol.

Bone healing pattern in surgically created circumferential defects around submerged implants: an experimental study in dog.

Marginal defects around titanium implants appeared to regenerate in 20-30 days by means of a distance osteogenesis.

Osseointegration of dental implants installed without mechanical engagement: a histometric analysis in dogs.

It can be conjectured that the submerged and unloaded SLA-surfaced implants could result in successful osseointegration, even if the mechanical engagement was not obtained at placement of the implants.



Appositional bone formation in marginal defects at implants.

The results suggest that healing of a wide marginal defect around an implant is characterized by appositional bone growth from the lateral and apical bone walls of the defect.

Dynamics of bone tissue formation in tooth extraction sites. An experimental study in dogs.

The healing of an extraction socket involved a series of events including the formation of a coagulum that was replaced by a provisional connective tissue matrix, woven bone, and lamellar bone and BM, and a hard tissue bridge--cortical bone--formed, which closed the socket.

Mechanisms of endosseous integration.

  • J. Davies
  • Medicine, Materials Science
    The International journal of prosthodontics
  • 1998
It is shown that peri-implant bone healing, which results in contact osteogenesis (bone growth on the implant surface), can be phenomenologically subdivided into three distinct phases that can be addressed experimentally.

The soft tissue barrier at implants and teeth.

Analysis and comparisons made between the structure and composition of clinically healthy supraalveolar soft tissues adjacent to implants and teeth demonstrated that the periimplant mucosa which formed at titanium implants following abutment connection had many features in common with gingival tissue at teeth.

A novel model system for the study of experimental guided bone formation in humans.

It is concluded that the presented model system is suitable to study temporal dynamics and tissue physiology of bone regeneration in humans with minimal risk for complications or adverse effects to the volunteers.

The topography of the vascular systems in the periodontal and peri-implant tissues in the dog.

The results of the present investigation demonstrated that the vasculature of the gingiva and the supracrestal connective tissue at teeth is derived from two sources, namely the supraperiosteal vessels lateral of the alveolar process and the vessels of the periodontal ligament.

Guided tissue regeneration in jawbone defects prior to implant placement.

The principle of guided tissue regeneration has been successfully applied for the regeneration of bone in various jaw defects in human to assess the bone volume regenerated using nonresorbable membrane barriers using Gore-Tex augmentation material.

Augmentation of the rat mandible using guided tissue regeneration.

Histological analysis demonstrated that, in 4 of 6 experimental specimens, the space created by the membrane was completely filled with new bone after 6 months of healing, but in some specimens soft tissue seemed to have migrated into the space through ruptures of the membrane or because of poor membrane adaptation at its lateral borders, thereby inhibiting bone formation.

Formation of jawbone tuberosities by guided tissue regeneration. An experimental study in the rat.

Findings indicate that a secluded space created by an occlusive barrier adjacent to existing bone or periosteum may be filled out with bone tissue, which may have a great clinical impact in cranial and maxillofacial surgery.

The jumping distance revisited: An experimental study in the dog.

It is concluded that a marginal defect wider than 1 mm may heal with new bone and a high degree of osseointegration to an implant designed with a SLA surface.