De novo acquisition of resistance to three antibiotics by Escherichia coli.

  title={De novo acquisition of resistance to three antibiotics by Escherichia coli.},
  author={Michael A van der Horst and Jasper Schuurmans and Marja C Smid and Belinda B Koenders and Benno H. ter Kuile},
  journal={Microbial drug resistance},
  volume={17 2},
The acquisition of resistance to amoxicillin, tetracycline, and enrofloxacin by Escherichia coli MG 1655 was examined by exposing growing cells to constant or stepwise increasing concentrations of these compounds. The minimal inhibitory concentration (MIC) of E. coli for amoxicillin increased from 4-8 to 32 μg/ml after growth in the presence of 1.25 or 2.5 μg/ml. By stepwise increasing the exposure, an MIC of 512 μg/ml was reached. This high MIC was maintained after removal of the antibiotics… CONTINUE READING

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