De novo GTP Biosynthesis Is Critical for Virulence of the Fungal Pathogen Cryptococcus neoformans

@article{Morrow2012DeNG,
  title={De novo GTP Biosynthesis Is Critical for Virulence of the Fungal Pathogen Cryptococcus neoformans},
  author={Carl A. Morrow and Eugene Valkov and Anna Stamp and Eve W L Chow and I. Russel Lee and Ania Wronski and Simon J. Williams and Justine M. Hill and Julianne Teresa Djordjevic and Ulrike Kappler and Bo{\vs}tjan Kobe and James Angus Fraser},
  journal={PLoS Pathogens},
  year={2012},
  volume={8}
}
We have investigated the potential of the GTP synthesis pathways as chemotherapeutic targets in the human pathogen Cryptococcus neoformans, a common cause of fatal fungal meningoencephalitis. We find that de novo GTP biosynthesis, but not the alternate salvage pathway, is critical to cryptococcal dissemination and survival in vivo. Loss of inosine monophosphate dehydrogenase (IMPDH) in the de novo pathway results in slow growth and virulence factor defects, while loss of the cognate… 

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