De novo FUS gene mutations are associated with juvenile-onset sporadic amyotrophic lateral sclerosis in China.

@article{Zou2013DeNF,
  title={De novo FUS gene mutations are associated with juvenile-onset sporadic amyotrophic lateral sclerosis in China.},
  author={Zhangyu Zou and Li-ying Cui and Qing Sun and Xiao-Guang Li and Ming-sheng Liu and Yan Xu and Yan Zhou and Xun-zhe Yang},
  journal={Neurobiology of aging},
  year={2013},
  volume={34 4},
  pages={1312.e1-8}
}
Juvenile amyotrophic lateral sclerosis (ALS) is a rare form of motor neuron disease and occurs before 25 years of age. Only very few sporadic cases of juvenile-onset ALS have been reported. Rare SOD1 mutations and several FUS mutations have been identified in juvenile-onset ALS patients. To define the genetics of juvenile-onset sporadic ALS (SALS) of Chinese origin, we sequenced all 5 exons of SOD1, exons 3-6 and 12-15 of FUS in 11 juvenile-onset SALS patients, 105 adult-onset ALS patients… CONTINUE READING