De Novo-Synthesized Retinoic Acid in Ovarian Antral Follicles Enhances FSH-Mediated Ovarian Follicular Cell Differentiation and Female Fertility.

Abstract

Retinoic acid (RA) is the active form of vitamin A and is synthesized from retinol by two key enzymes, alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH). As the physiological precursor of RA, retinol impacts female reproductive functions and fertility. The expression of Adh1 and Adh5 as well as Aldh1a1 and Aldh1a7 are significantly increased… (More)
DOI: 10.1210/en.2015-2064

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@article{Kawai2016DeNR, title={De Novo-Synthesized Retinoic Acid in Ovarian Antral Follicles Enhances FSH-Mediated Ovarian Follicular Cell Differentiation and Female Fertility.}, author={Tomoko Kawai and Noriyuki Yanaka and Joanne S Richards and Masayuki Shimada}, journal={Endocrinology}, year={2016}, volume={157 5}, pages={2160-72} }