De Novo Prediction of PTBP1 Binding and Splicing Targets Reveals Unexpected Features of Its RNA Recognition and Function

Abstract

The splicing regulator Polypyrimidine Tract Binding Protein (PTBP1) has four RNA binding domains that each binds a short pyrimidine element, allowing recognition of diverse pyrimidine-rich sequences. This variation makes it difficult to evaluate PTBP1 binding to particular sites based on sequence alone and thus to identify target RNAs. Conversely… (More)
DOI: 10.1371/journal.pcbi.1003442

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Cite this paper

@inproceedings{Han2014DeNP, title={De Novo Prediction of PTBP1 Binding and Splicing Targets Reveals Unexpected Features of Its RNA Recognition and Function}, author={Areum Han and Peter Stoilov and Anthony J. Linares and Yu Zhou and Xiang-Dong Fu and Douglas L. Black}, booktitle={PLoS Computational Biology}, year={2014} }