De Novo MYC and BCL2 Double-hit B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) in Pediatric and Young Adult Patients Associated With Poor Prognosis.

@article{Liu2015DeNM,
  title={De Novo MYC and BCL2 Double-hit B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) in Pediatric and Young Adult Patients Associated With Poor Prognosis.},
  author={Wei Liu and Shimin Hu and Marina Y Konopleva and Joseph D Khoury and Neda Kalhor and Guilin Tang and Carlos E Bueso-Ramos and Jeffrey L. Jorgensen and Pei Lin and L Jeffrey Medeiros and Xinyan Y Lu},
  journal={Pediatric hematology and oncology},
  year={2015},
  volume={32 8},
  pages={535-47}
}
MYC and BCL2 translocations in B-cell lymphomas are defined as "double-hit" associated with poor prognosis in adult patients. Such double-hit events are extremely rare in B-cell precursor acute lymphoblastic leukemia (BCP-ALL), especially in pediatric patients or young adults. This study is to investigate the clinical manifestation of de novo MYCyBCL2 double-hit BCP-ALL in young patients. Two pediatric and one young adult patients were identified after a retrospective data review and all… CONTINUE READING