De Novo Genesis of Enhancers in Vertebrates

  title={De Novo Genesis of Enhancers in Vertebrates},
  author={Michael P. Eichenlaub and Laurence M Ettwiller},
  booktitle={PLoS biology},
Evolutionary innovation relies partially on changes in gene regulation. While a growing body of evidence demonstrates that such innovation is generated by functional changes or translocation of regulatory elements via mobile genetic elements, the de novo generation of enhancers from non-regulatory/non-mobile sequences has, to our knowledge, not previously been demonstrated. Here we show evidence for the de novo genesis of enhancers in vertebrates. For this, we took advantage of the massive gene… CONTINUE READING
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