De Novo Generation of a Unique Cervid Prion Strain Using Protein Misfolding Cyclic Amplification

Abstract

Substantial evidence supports the hypothesis that prions are misfolded, infectious, insoluble, and protease-resistant proteins (PrPRES) devoid of instructional nucleic acid that cause transmissible spongiform encephalopathies (TSEs). Protein misfolding cyclic amplification (PMCA) has provided additional evidence that PrPRes acts as a template that can… (More)
DOI: 10.1128/mSphere.00372-16

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