De Novo Formation of Left–Right Asymmetry by Posterior Tilt of Nodal Cilia

@article{Nonaka2005DeNF,
  title={De Novo Formation of Left–Right Asymmetry by Posterior Tilt of Nodal Cilia},
  author={Shigenori Nonaka and Satoko Yoshiba and Daisuke Watanabe and Shingo Ikeuchi and Tomonobu Goto and Wallace F. Marshall and Hiroshi Hamada},
  journal={PLoS Biology},
  year={2005},
  volume={3},
  pages={103 - 113}
}
In the developing mouse embryo, leftward fluid flow on the ventral side of the node determines left-right (L-R) asymmetry. However, the mechanism by which the rotational movement of node cilia can generate a unidirectional flow remains hypothetical. Here we have addressed this question by motion and morphological analyses of the node cilia and by fluid dynamic model experiments. We found that the cilia stand, not perpendicular to the node surface, but tilted posteriorly. We further confirmed… CONTINUE READING

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